Where is nitroglycerine metabolized?

Where is nitroglycerine metabolized?

Metabolism: A liver reductase enzyme is of primary importance in the metabolism of nitroglycerin to glycerol di- and mononitrate metabolites and ultimately to glycerol and organic nitrate. Known sites of extrahepatic metabolism include red blood cells and vascular walls.

Why is topical nitroglycerin systemic use?

Nitroglycerin ointment (Nitro-Bid) is used to prevent episodes of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart).

How is sublingual nitroglycerin absorbed?

Nitroglycerin sublingual tablets should not be chewed, crushed, or swallowed. They work much faster when absorbed through the lining of the mouth. Place the tablet under the tongue or between the cheek and gum, and let it dissolve.

Can you absorb nitroglycerin?

The available findings from in vivo and in vitro studies in both humans and animals show that nitroglycerin can be absorbed through the skin. No dermal lethal concentration (LDLo) for humans has been identified.

What is a common side effect of nitroglycerin?

Side Effects Headache, dizziness, lightheadedness, nausea, flushing, and burning/tingling under the tongue may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Headache is often a sign that this medication is working.

How long does nitroglycerin stay in your system?

6. Response and effectiveness. Nitroglycerin acts in the body for an extremely short period (the half-life is 1 to 4 minutes), although it is metabolized to longer-lived active metabolites.

How long does nitroglycerin ointment stay in your system?

It will not relieve an attack that has already started because it works too slowly. The ointment and patch forms release medicine gradually to provide an effect for 7 to 10 hours.

Why is nitroglycerin given sublingually instead of orally?

Glyceryl trinitrate (or nitroglycerin) undergoes extensive hepatic presystemic metabolism when given orally. Therefore, it is usually given by the sublingual route, by which it is well absorbed and rapidly taken up into the circulation.

Does nitroglycerin explode if dropped?

Nitroglycerin is an oily, colourless liquid, but also a high explosive that is so unstable that the slightest jolt, impact or friction can cause it to spontaneously detonate. It is the speed of the decomposition reaction which makes nitroglycerin such a violent explosive.

How long does it take for nitroglycerin to be absorbed?

Pharmacokinetics and Drug Metabolism Absorption: Nitroglycerin is rapidly absorbed following sublingual administration of Nitrostat tablets. Mean peak nitroglycerin plasma concentrations occur at a mean time of approximately 6 to 7 minutes postdose (Table 1).

When does nitroglycerin peak after sublingual administration?

Nitroglycerin is rapidly absorbed following sublingual administration of Nitrostat tablets. Mean peak nitroglycerin plasma concentrations occur at a mean time of approximately 6 to 7 minutes postdose (Table 1).

What should you not do while taking nitroglycerin tablets?

Do not eat, drink, smoke, or use chewing tobacco while a tablet is dissolving. Nitroglycerin sublingual tablets usually give relief in 1 to 5 minutes. However, if the pain is not relieved, you may use a second tablet 5 minutes after you take the first tablet.

What is the absolute bioavailability of nitroglycerin tablets?

The absolute bioavailability of nitroglycerin from Nitrostat tablets is approximately 40% but tends to be variable due to factors influencing drug absorption, such as sublingual hydration and mucosal metabolism. Table 1 Mean Nitroglycerin (SD) Values Parameter 2 × 0.3 mg Nitrostat Tablets 1 × 0.6 mg Nitrostat Tablets C max